Implementation of vaccines to control poliomyelitis

2017-03-22


Development and application of live attenuated polio vaccine in China


Poliomyelitis live vaccines could prevent the type I, II, III poliovirus infections, is one of the most economical and efficient poliomyelitis vaccine, which has been used for more than 50 years in our country. Because our government vigorously promote the implementation of the immunization strategy, China had no found reported cases caused by local wild strain, since October 1994. Poliomyelitis could be effectively controled, which had been called "a threat to children's life and health of the biggest killers of paralysis". In October 2000, China was declared polio-free by the Regional Commission for the Certification of Poliomyelitis Eradication (RCC) in WHO Western Pacific Region. This is a great performance of the world public health history after the global eradication of smallpox, the protection tens of millions children's physical and mental health, very greatly improve the quality of the population.

 

 As China's largest polio vaccine production and research base, the mission of the Institute of Medical Biology is to develop and resarch of Poliomyelitis vaccines. The institute developed the first oral polio live attenuated, and the first new form Poliomyelitis Vaccine in Dragee Candy, under the guidance of the first generation of scientists. With the implementation of the WHO polio program, the institute has developed the whole series of national immunization polio vaccines ,such as Oral Poliomyelitis live vaccines(monkey kidney cell) ,Poliomyelitis live vaccines(human diploid cell), I+III Poliomyelitis live vaccines(human diploid cell), provided a strong guarantee for the polio-free status in our country.


Leap of our vaccine from “made in China “to” created in China”

--Sabin strains of inactivated polio vaccine successfully listed


Sabin strains of inactivated polio vaccine (sIPV) are created by the Chinese Academy of Medical Sciences Institute of Medical Biology (hereinafter referred to as Institute of biology) after nearly 30 years of research and development. Sabin strain of polio virus and Vero cells matrix are provided by the World Health Organization (WHO), on the application of international advanced technology of micro carrier bioreactor culture. Sabin IPV has had successful development of National prevention Bioproducts class 1 new medicine. On January 14, 2015, sIPV approved by the State foodand drug administration, became the first inactivated Sabin strain of polio vaccine.

 

As China's major innovative products have complete independent intellectual property rights, sIPV successfully realize the vaccine from "made in China" to "created in China". It not only fills the gaps in the field of inactivated polio vaccine production in China also broke the monopoly of inactivated polio vaccine production technology in developed countries, for our country and the world, particularly developing countries, the eradication of polio will have a positive impact, will be the end of the global polio eradication strategy must be the best weapon. WHO also wrote to the relevant departments of China, sIPV of China was put forward in the global polio eradication initiative. In July 2015, China Academy of medical biology of Kunming high-tech developmental zone "biological vaccine industry base," produced the first sIPV, achieve the goal of the China children vaccinated China innovative vaccines. Marketing and use of sIPV, will enable our country to continue to rely on Chinese innovation and own power, independent and complete eradication of polio Wild virus andpolio virus derived, China several generations of polio vaccine researchers’ ideals, " insulated polio on the Chinese children" .