Functions of Hippo signaling pathway in development, regeneration and carcinogenesis


Professor Duojia Pan will deliver a speech entitled in “Functions of Hippo signaling pathway in development, regeneration and carcinogenesis”.


Time: 14:00-17:00, April 11, 2017;

Venue: the PUMC’s Auditorium.


Professor Duojia Pan is the Chairman of Department of Physiology at US Southwestern Medical Center, and an Investigator of the Howard Hughes Medical Institute.


Academic Background:

Dr. Pan obtained B.S. in Biochemistry from Peking University(1988), Ph.D. in Biological Chemistry from UCLA(1993), and a postdoctoral fellowship with Gerald Rubin at UC Berkeley (1993-1998). Prior to his current position, Dr. Pan was on the faculty at Johns Hopkins University (2004-2006).


Dr. Pan investigates the molecular mechanisms of growth control and tissue homeostasis. He is best known for pioneering work on the Hippo signaling pathway, an evolutionarily conserved developmental pathway that controls organ size in all animals. Using Drosophila as a model, his laboratory made a series of discoveries that defined, in a stepwise manner, the key molecular events in the Hippo signaling pathway. His team further established a critical role for the Hippo pathway in contrilling manmmalian organ size, regeneration and tumorigenesis. Besides research on the Hippo pathway, the Pan laboratory also elucidated the molecular function of the Tsc1 and Tsc2 tumor suppressor genes, linking Tsc1 / Tsc2 tumor suppressor genes, linking Tsc1 / Tsc2 to Rhed and TOR signaling. This work provided the key molecular insight for the use of mTOR inhibitors in the treatment of Tuberous Sclerosis. His current efforts are aimed at understanding the composition, mechanism and regulation of the Hippo pathway, elucidating its physiological roles in normal development and disease, and discovery of chemical probes targeting the Hippo pathway.


Welcome to join us!